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Riboflavin supplementation in migraineVitamin B2 or riboflavin has been found to significantly decrease the frequency of migraine headaches. In one European study involving 55 migraine patients, high dose riboflavin (400 mg per day) was effective in reducing migraines by at least 50 present in the majority of patients. This dose is significantly higher than the amount of riboflavin usually found in multivitamins. Riboflavin is a precursor of certain enzymes involved in brain energy production. It likely acts by raising the threshold necessary to induce a migraine headache. Riboflavin is inexpensive, costing approximately $10.00 per month. It is sometimes difficult to find in this dose (400 mg). If you have difficulty locating a pharmacy that carries this dosage strength, contact out office. Riboflavin is generally very well tolerated. The urine color may change to a brighter yellow when taking riboflavin. Often, the benefits of riboflavin become significant only after three or four months, emphasizing the need to be patient. Keeping a headache diary can be very helpful in measuring the success of a preventive treatment such as riboflavin. Results of recent studies involving riboflavin are encouraging. Large scale studies have yet to be done, but early one riboflavin looks to be a safe, inexpensive, effective way to decrease the frequency of migraine headaches.
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