Center for Integrative Research on Cardiovascular Aging (CIRCA)
Promoting Wellness and Healthy Aging
Aurora Health Care helps people live well through research innovation. The Research team at Aurora Health Care is committed to providing cutting edge research in the laboratory, integrating this knowledge at the patient’s bedside and communicating these valuable patient-centered discoveries to the community.
Patient-centered outcomes are the focus of research at Aurora Health Care, and the new Center for Integrative Research on Cardiovascular Aging (CIRCA) is an integral part of this research mission. The CIRCA team complements the existing research programs in interventional cardiology, cardiac electrophysiology, cardiac imaging, heart failure, preventive cardiology, integrative medicine, regenerative medicine and biomedical research, among others.
The mission of CIRCA is to support and conduct clinical and basic research on the biology of aging and to develop diagnostic, predictive and therapeutic interventions to preserve wellness, prevent age-related cardiovascular dysfunction and improve the quality of life of the community. CIRCA’s research program is supported by the National Heart, Lung and Blood Institute of the National Institutes of Health. With the aging of the population, the prevalence of cardiovascular disabilities is projected to increase and greatly impact healthcare resource utilization, highlighting the need to implement strategies to limit cardiovascular dysfunction with aging. The focus of CIRCA's research is on uncovering the molecular and cellular determinants of disease risk, as well as changes that occur with age at the organ, tissue, cellular, and molecular levels that increase susceptibility to myocardial dysfunction . The team translates this knowledge into clinical practice to improve diagnostic, predictive and therapeutic capabilities for disease prevention and health maintenance.
By exploring the molecular mechanisms responsible for the aging heart’s decreased stress tolerance and enhanced susceptibility to arrhythmogenesis, the team seeks to develop novel strategies for early detection of disease susceptibility and design interventions to protect the heart. This enables medical providers to prevent, avert or treat abnormalities before overt disease. The long-term goal of CIRCA to promote highest quality clinical care, education and research to support healthy cardiovascular aging
Arshad Jahangir, MD, is the director for CIRCA, and a professor of medicine at the Aurora University of Wisconsin Medical Group (AUWMG) University of Wisconsin School of Public Health and Medicine. Before joining Aurora Health Care, he was professor of medicine and director of the CardioGerontology Research Laboratory at Mayo Clinic, where he worked for 21 years. Dr. Jahangir directs a team of multidisciplinary researchers, including Ekhson Holmuhamedov, PhD, Larisa Emelyanova, PhD, Farhan Rizvi, PhD, Gracious Ross, PhD and Mahek Mirza, MD, and other research staff whose specialized background in clinical and basic research puts them in a unique position to examine the molecular basis for cardiovascular aging.
The CIRCA team works closely with other academic centers and the community to provide opportunities for health care providers and the public to become a part of this important research. This partnership will advance awareness about prevention of aging-associated cardiovascular diseases, helping to reduce the burden of aging associated diseases and to help people live well.