Center for Integrative Research on Cardiovascular Aging
Arshad Jahangir, MD
Dr. Jahangir graduated from the Dow Medical College at the University of Karachi (India). He completed his residency in internal medicine and fellowships in cardiology and cardiac electrophysiology at the Mayo Clinic in Rochester, Minnesota. He serves as director of the Center for Integrative Research on Cardiovascular Aging (CIRCA) and the chair for the Cardiovascular Research at Aurora. He is also a professor of medicine for Aurora University of Wisconsin Medical Group (AUWMG) and University of Wisconsin School of Medicine and Public Health. As a clinician-investigator, Dr. Jahangir brings an extensive expertise in clinical and basic cardiac electrophysiology and cardiac aging.
Dr. Jahangir has served in a leadership role for several national and international clinical and scientific societies. He currently serves as a member of the Myocardial Ischemia and Metabolism Study Section at the National Heart, Lung and Blood Institute (NHLBI). He has also published extensively in the field of cardiovascular disease and served as a reviewer for several peer reviewed journals. Dr. Jahangir is the recipient of numerous national and international awards. He received the William B Abrams Award in Geriatric Clinical Pharmacology and multiple awards from Mayo Clinic for his research in cardiovascular aging.
Dr. Jahangir is a clinician investigator with expertise in clinical and basic cardiac electrophysiology, and research interest in cardiac aging and arrhythmogenesis. His research program has been supported by the National Heart Blood and Lung Institute (NHLBI), National Institute on Aging, American Heart Association, Society of Geriatric Cardiology, Institutional grants from Mayo Clinic and Aurora Health Care. He currently holds two NHLBI RO1 grants that focus on aging and cardio-protection and the role of mitochondria in atrial fibrillation.
Ekhson Holmuhamedov, PhD
Dr. Holmuhamedov graduated from the Institute of Biological Physics Union of Soviet Socialists Republics with a PhD degree in Biological Physics. He also holds a Doctor of Science (DSc) degree from Institute of Theoretical and Experimental Biophysics, Russian Federation.
Dr. Holmuhamedov is a research scientist at the Center for Integrative Research on Cardiovascular Aging (CIRCA). He has served as a faculty member at different institutions, including NASA Ames Research Center, Moffett Field (California), research associate professor at Mayo Clinic (Rochester, MN) Assistant Professor at University of North Carolina (Chapel Hill, NC) and more recently as associate professor at the Medical University of South Carolina.
Dr. Holmuhamedov’s research is focused on mitochondrial physiology and cellular bioenergetics, linking the role of mitochondria and human disease. His research has been continually supported by grants from the National Institute of Aging, the NHLBI and the National Institute on Alcohol Abuse and Alcoholism, as well as the American Heart Association. Currently, he holds two RO1 grants through NHLBI that focus on aging and protecting against atrial fibrillation with Dr. Jahangir.
Dr. Holmuhamedov is a well-recognized expert in the mitochondrial field and has contributed in this field. He has published original research in several peer reviewed journals including Nature, Journal of Biological Chemistry, Biochemical Biophysical Acta, Archives of Biochemistry, Proceeding of the National Academy of Sciences and others.
Mahek Mirza, MD
Dr. Mirza graduated from the Dow Medical College at University of Karachi, Pakistan with a Bachelor of Medicine and Bachelor of Science degree. She has worked as a research trainee and fellow in the CardioGerentology Research Lab at Mayo Clinic (Arizona) under the guidance of Dr. Jahangir. Dr. Mirza is a research associate for the CIRCA and is a fellow for the Aurora University of Wisconsin Medical Group (AUWMG).
Her research interests focus on the role of aging on atrial structural and functional changes that increases predisposition to atrial fibrillation in the elderly. Dr. Mirza is currently working on several research projects to obtain mechanistic insights into the role of aging in cardiovascular disease, and to define the impact of aging on cardiovascular outcomes in patients with life threatening ventricular arrhythmias and atrial fibrillation. She first described the impact of severity of restless leg syndrome on cardiac structural and functional changes that result in left ventricular hypertrophy.
Dr. Mirza is a member of the American Society of Clinical Pharmacology & Therapeutics and is an ad-hoc reviewer for the Journal of American Geriatric Society, and Cardiology Research and Practice. She has presented and published her research work in peer reviewed journals. She has also reviewed articles for the American Geriatrics Society and the American College of Cardiology. Her research work is supported by funding from the National Institutes of Health (NIH).
Larisa Emelyanova, PhD
Dr. Emelyanova earned her PhD from the Laboratory of Comparative Biochemistry of Inorganic Ions at the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences in Saint-Petersburg, Russia.
She was a postdoctoral fellow for CardioGerentology at Mayo Clinic in Arizona and a fellow at the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences. She is presently a research scientist for CIRCA and a postdoctoral fellow at the Aurora University of Wisconsin Medical Group (AUWMG).
She is currently pursuing a research fellowship under the guidance of Dr. Jahangir on understanding the mechanism of increased susceptibility of the elderly to atrial fibrillation. She has extensive experience in cellular physiology in the field of mitochondrial energetics, with a particular interest in defining the role of mitochondria in animal models of metabolic stress.
Dr. Emelyanova is a member of several scientific societies, as well as presented her original research work at national and international meetings, and has several publications in peer reviewed journals.
Dr. Gracious Ross, PhD
Dr. David Wang, MD, PhD
Resident Internal Medicine and Research Fellow
Farhan Rizvi, PhD
Dr. Rizvi graduated from the University of Mumbai, India with a PhD in Biological Science. Before joining CIRCA, Dr. Rizvi was an International guest scientist at University of Uppsala in Sweden. Most recently, he was a senior postdoctoral fellow at Medical College of Wisconsin in Milwaukee.
He is currently investigating the role of microRNA targeting cardiac fibrosis, and the mechanism of cell death and differentiation in cardiac aging and disease. He has extensive experience in cell death and disease, signal transduction, gene regulation, epigenetics, and metabolic syndrome.
Dr Rizvi has international patents for discovering the agents for treatment of prophylaxis of diabetic and related metabolic disorders. He has published original research in several peer reviewed journals, including Circulation Research, PloS One, Journal of Lipid Research and Molecular Vision. He also serves as a reviewer to various journals.
Gracious Ross, PhD
David Wang, MD, PhD
Resident Internal Medicine and Research Fellow