Hepatitis B Vaccine
(Hep B Vaccine)
What Is Hepatitis B?
Hepatitis B is a disease caused by the hepatitis B virus (HBV). This virus attacks the liver. The disease can cause:
HBV is spread through the blood or other body fluids of an infected person.
Certain factors increase the risk of developing hepatitis B, including:
About 30% of people with hepatitis B will not have symptoms. For people who do, symptoms may include:
Symptoms generally occur about 12 weeks after exposure. They can occur anywhere from 9-21 weeks after exposure. Most hepatitis B infections clear up within 1-2 months without treatment. But when an infection lasts more than six months, it can develop into chronic hepatitis B. This can lead to serious complications, even death.
Chronic hepatitis B can be treated with antiviral drugs.
What Is the Hepatitis B Vaccine?
The hepatitis B vaccine is produced by inserting a gene for HBV into yeast. The yeast is grown, harvested, and purified. The vaccine is given as an injection into the muscle.
Who Should Get Vaccinated and When?
Newborns routinely receive the first dose of the hepatitis B vaccine before leaving the hospital. If the mother is infected with the virus, the dose is given within 12 hours of birth. Two more injections are given to all infants at:
Depending on the type of vaccine, some babies may receive 4 doses.
Children and teens (aged 18 years or younger) who have not been immunized as babies can also get the vaccine. For children aged 11-15 years, there is a two-dose series available, called Recombivax HB.
It is recommended that adults (aged 18 years or older) get vaccinated if they are at high risk for hepatitis B. High risk includes:
What Are the Risks Associated With the Hepatitis B Vaccine?
All vaccines are capable of causing serious problems, such as a severe allergic reaction.
Most people who get the hepatitis B vaccine do not have problems. Some may have mild problems, including soreness where the shot was given and fever.
Acetaminophen (eg, Tylenol) is sometimes given to reduce pain and fever that may occur after getting a vaccine. In infants, the medicine may weaken the vaccine's effectiveness. Discuss the risks and benefits of taking acetaminophen with the doctor.
Who Should Not Get Vaccinated?
You should not get the vaccine if you:
What Other Ways Can Hepatitis B Be Prevented Besides Vaccination?
Other than getting the hepatitis B vaccine, the best methods of preventing an HBV infection include:
What Happens in the Event of an Outbreak?
In the event of an outbreak, all susceptible people should be offered the vaccine.
WHERE CAN I GET MORE INFORMATION?
National Digestive Diseases Information Clearinghouse
National Immunization Program
Baker CJ, Pickerling LK, Chilton L, et al. Advisory Committee on Immunization Practices. Recommended adult immunization schedule: United States, 2011. Ann Intern Med. 2011;154(3):168-173.
Centers for Disease Control and Prevention. Recommended immunization schedules for persons aged 0-18 years—United States, 2011. MMWR. 2011;60(5).
Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR 2010;59(No. RR-12):1-110.
Hepatitis B. National Center for Infectious Diseases website. Available at: http://www.cdc.gov/ncidod/ . Accessed February 6, 2007.
Hepatitis B. US Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/ncidod/diseases/hepatitis/b/factvax.htm . Accessed February 6, 2007.
Hepatitis B vaccination. US Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/vaccines/vpd-vac/hepb/default.htm . Accessed February 6, 2007.
Recommended immunization schedules for persons aged 0-6 years—United States, 2012. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov... . Published December 23, 2011. Accessed February 10, 2012.
Vaccine information statement: hepatitis B vaccine. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-hep-b.pdf . Updated February 2, 2012. Accessed February 10, 2012.
1/31/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Centers for Disease Control and Prevention. Recommended immunization schedules for persons aged 0-18 years—United States, 2008. MMWR. 2008;57;Q1-Q4. Centers for Disease Control and Prevention, MMWR website. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5701a8.htm . Updated January 10, 2008. Accessed January 28, 2008.
10/30/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Prymula R, Siegrist C, Chlibek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet . 2009;374(9698):1339.
Last reviewed June 2012 by Lawrence Frisch, MD, MPH