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Conditions InDepth: SclerodermaMain Page | Risk Factors | Symptoms | Diagnosis | Treatment | Screening | Reducing Your Risk | Talking to Your Doctor | Living With Scleroderma | Resource Guide Scleroderma is a disease of the body’s connective tissue. Connective tissue is found throughout the body, providing support and form for organs and structures. Scleroderma is thought to be an autoimmune disorder—a condition in which the immune system mistakes the body’s own tissue for a foreign invader, attacking and damaging it. Researchers believe that the immune system’s interaction with the connective tissue causes an overproduction of collagen—a tough, hard protein that makes up tendons, bones, ligaments, and scar tissue. When this collagen is deposited in various places throughout the body, it causes hardening and stiffening. The most common areas of the body affected by scleroderma are the skin, blood vessels, joints, and internal organs (heart, lungs, kidneys, and digestive system). Scleroderma  © 2009 Nucleus Medical Media, Inc. Scleroderma is classified as: Localized Scleroderma—This primarily affects the skin. Localized scleroderma is further divided into:
Generalized Scleroderma —This is divided into:
Systemic Sclerosis Sine Scleroderma —This is a very rare form of scleroderma in which there are no skin manifestations, but the internal organs are affected. Scleroderma is relatively rare, affecting about 150,000 Americans. Worldwide, there are about 500 cases of scleroderma in every one million people. What are the risk factors for scleroderma? References: Harrison’s Principles of Internal Medicine. 15th ed. McGraw-Hill; 2001. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/ . Scleroderma Foundation website. Available at: http://www.scleroderma.org/ . Last reviewed December 2009 by Jill D. Landis, MD Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. Copyright © 2009 EBSCO Publishing All rights reserved.
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