Santhi Konduri, PhD

Senior Research Scientist


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Aurora Research Institute
960 N. 12th Street, Suite 4120
Milwaukee, WI 53233 

Senior Research Scientist Santhi Konduri, PhD

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Overview

Dr. Konduri is a translational cancer researcher for Aurora Research Institute with an interest in cancer therapeutics, particularly in the areas of preventing drug resistance and drug discovery and development. She is focused on targeted therapies to treat brain, breast and pancreatic cancers.

By working to identify and characterize the genes that cause tumor resistance to chemotherapy, the central reason for treatment failure in patients with cancer, Dr. Konduri hopes to discover new options to treat or even prevent cancers. Her research has led to promising findings in combination therapies, including chemotherapy and immunotherapy. These new research findings may lead to therapies that offer minimal toxicity to healthy cells while specifically targeting cancer cells, which could result in fewer unwanted treatment side effects to cancer patients.

With more than 100 scholarly works and abstract presentations, Dr. Konduri has shared data generated in the laboratory with the greater scientific community. She soon hopes to begin multiple clinical trials that will positively impact the lives of patients with cancer.

Education

Doctorate, Human Genetics
Andhra University, Visakhapatnam, India

Master of Science, Human Genetics
Andhra University, Visakhapatnam, India

Bachelor of Science, Chemistry
Andhra University, Visakhapatnam, India

Professional highlights

Aurora Cancer Care Research Award recipient, Preclinical Evaluation of Disulfiram as Part of Combination Therapy in Breast and Pancreatic Cancers, Vince Lombardi Cancer Foundation, 2014-2015

Senior Research Scientist and Assistant Professor, Oncology, MD Anderson Cancer Center, Orlando, Florida, 2006-2013

Research Affiliate, Department of Molecular Phamacology and Cancer Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, 2002-2006

Publications

Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. J Biomed Res. 2016;30:393-410.

Bobustuc GC, Patel A, Thompson M, Srivenugopal KS, Frick J, Weese J, Konduri SD. MGMT inhibition suppresses survivin expression in pancreatic cancer. Pancreas. 2015;44:626-635.

Bobustuc GC, Baker CH, Limaye A, Jenkins WD, Pearl G, Avgeropoulos NG, Konduri SD. Avgeropoulos NG, Konduri SD. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol. 2010;12:917-927.

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